Key result
Combined therapy with low dose atorvastatin 10 mg, aspirin, clopidogrel, and smoking cessation for one year resulted in the spontaneous recanalization of a previously totally occluded left anterior descending coronary artery.
Why the study?
Does the combination of low-dose atorvastatin, aspirin, clopidogrel, and smoking cessation lead to recanalization of a totally occluded LAD in a young obese patient?
Case Report (n=1)
No
Does the combination of low-dose atorvastatin, aspirin, clopidogrel, and smoking cessation lead to recanalization of a totally occluded LAD in a young obese patient?
Spontaneous recanalization of a totally occluded LAD was observed after one year of low-dose atorvastatin, dual antiplatelet therapy, and smoking cessation in a young patient.
A 39-year-old physician had severe central chest pain and cardiogenic shock due to acute inferior myocardial infarction one year ago; bare metal stent was inserted into occluded right coronary artery, culprit artery. Left anterior descending artery (LAD) was found to be totally occluded too, planned for future procedure. He had multiple risk factors: high BMI 28, heavy smoking, high cholesterol 220 mg% and sedentary life style. He quit smoking after the event. He has been taking atorvastatin 10 mg, aspirin 75 mg and clopidogrel 75 mg in addition to diuretics and low dose ramipril. He could not do exercise as his effort tolerance was poor. One year later, recheck coronary angiogram revealed a good flow in right coronary artery; moreover, there was distal flow in totally occluded LAD. Therefore, bare metal stent was inserted after dilatation. Blood tests were almost the same. In this patient, spontaneous flow in totally occluded LAD was due to combined effect of low dose atorvastatin, aspirin, clopidogrel and cessation of smoking for one year; not due to exercise or weight reduction. Low dose statin and smoking cessation had effect on atheromatous plaque on LAD.
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Khin Phyu Pyar (2022) conducted a case report in Totally occluded left anterior descending coronary artery (n=1). Low dose atorvastatin, aspirin, clopidogrel, and smoking cessation was evaluated on Recanalization of totally occluded LAD. Combined therapy with low dose atorvastatin 10 mg, aspirin, clopidogrel, and smoking cessation for one year resulted in the spontaneous recanalization of a previously totally occluded left anterior descending coronary artery.
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