December 1, 1982Lipids

Characteristics of the formation of the platelet lipoxygenase product from endogenous arachidonic acid

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Population

Rat platelets (from control and essential fatty acid deficient [EFAD] rats)

Comparison

Collagen suspension-induced aggregation and… vs Comparison between control and EFAD rat…

Design

Preclinical

Follow-up

115 minutes (incubation period)

Authors

DHDaniel HwangPennington Biomedical Research Center

Discussion

Member takes

Implication

May indicate sustained platelet lipoxygenase activity; leaves open relevance to human thrombosis or inflammation.

Structured PICO

Population

Rat platelets (from control and essential fatty acid deficient [EFAD] rats)

Intervention

Collagen suspension-induced aggregation and incubation

Comparator

Comparison between control and EFAD rat platelets resuspended in different plasma

Outcome

Concentration of 12-HETE, TXB2, and PGF2 alpha over timesurrogate

Platelet lipoxygenase remains active longer than cyclooxygenase after stimulation, suggesting its products may have more persistent physiological effects.

Cite This Study

Daniel Hwang (1982) studied this question.

synapsesocial.com/papers/6a1ff1827110a651dc04bdc1 https://doi.org/10.1007/bf02534576

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Characteristics of the formation of the platelet lipoxygenase product from endogenous arachidonic acid

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characteristics of the formation of the platelet lipoxygenase product from endogenous arachidonic acid

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider