What is the clinical evidence from this study?

Study design: Other. Population: Platelet activation. Intervention: 12(S)-HETE. Primary outcome: CD62 (P-selectin) expression.

January 1, 1998Platelets

12(S)-HETE plays a role as a mediator of expression of platelet CD62 (P-selectin)

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Key result

Exogenously added 12(S)-HETE enhanced CD62 expression, indicating that 12-lipoxygenase products play a role as a second messenger for platelet activation.

Authors

TYTao YanNorth China Electric Power University

Discussion

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Implication

No immediate clinical implications for antiplatelet therapy; leaves open 12-lipoxygenase targeting in thrombosis.

PICO

Population

Platelet activation

Intervention / Comparator

12(S)-HETE

Primary Outcome

CD62 (P-selectin) expression

Cite This Study

Tao Yan (1998) studied Platelet activation. 12(S)-HETE was evaluated on CD62 (P-selectin) expression. Exogenously added 12(S)-HETE enhanced CD62 expression, indicating that 12-lipoxygenase products play a role as a second messenger for platelet activation.

synapsesocial.com/papers/6aa0a405a4cd221e9c66704b https://doi.org/10.1080/09537109876537

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12(S)-HETE plays a role as a mediator of expression of platelet CD62 (P-selectin)

Discussion

Member takes

Implication

PICO

Cite This Study

12(S)-HETE plays a role as a mediator of expression of platelet CD62 (P-selectin)

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider