Key result
Intravenous vessel dilator increased urine flow 2- to 13-fold (P<0.001) and sodium excretion 3- to 4-fold (P<0.01) in patients with NYHA class III congestive heart failure.
Why the study?
Does intravenous vessel dilator improve diuresis, natriuresis, and hemodynamics in patients with NYHA class III congestive heart failure?
Population
NYHA class III congestive heart failure (CHF) subjects
Comparison
Vessel dilator given intravenously for 60 minutes vs Control CHF patients
Design
Other
Follow-up
3 hours post-infusion
Authors
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May augment diuresis in NYHA III HF; leaves open outcome effects and need for randomized trials.
Does intravenous vessel dilator improve diuresis, natriuresis, and hemodynamics in patients with NYHA class III congestive heart failure?
Effect estimate: 2- to 13-fold increase
p-value: p=<0.001
Intravenous vessel dilator significantly enhances diuresis and natriuresis while improving central hemodynamics in patients with severe heart failure.
Vesely et al. (1998) studied Congestive Heart Failure. Vessel dilator vs. Control CHF patients was evaluated on Urine flow (2- to 13-fold increase, p=<0.001). Intravenous vessel dilator increased urine flow 2- to 13-fold (P<0.001) and sodium excretion 3- to 4-fold (P<0.01) in patients with NYHA class III congestive heart failure.
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