Key result
Plasmapheresis successfully reduced severe hypertriglyceridemia from 9475 mg/dL to 128 mg/dL in a COVID-19 patient, coinciding with remarkable clinical improvement and successful extubation.
Why the study?
Most laboratory findings of COVID-19 are neither specific nor reliable for assessing treatment response.
Does plasmapheresis improve clinical status and reduce triglyceride levels in a patient with severe COVID-19 and extreme hypertriglyceridemia?
Case Report (n=1)
No
Does plasmapheresis improve clinical status and reduce triglyceride levels in a patient with severe COVID-19 and extreme hypertriglyceridemia?
Plasmapheresis targeting normal triglyceride levels may be an effective rescue therapy for severe COVID-19 patients presenting with extreme hypertriglyceridemia and cytokine storm.
May support plasmapheresis in refractory COVID-19 hypertriglyceridemia; hypothesis-generating and requires prospective trials.
Most laboratory findings of coronavirus disease (COVID-19) are not specific nor are they reliable in assessing response to treatments. This case report outlines a rare finding of severe hypertriglyceridemia in a COVID-19 patient and, more interestingly, it sheds light on a correlation between clinical improvement and a decrease in hypertriglyceridemia after plasmapheresis treatment. Using a normal triglyceride level as a target for our plasmapheresis treatment resulted in dramatic improvement in our patient’s condition. The patient was treated successfully and discharged from the hospital after nine days.
No takes yet. Share an insight, caveat, or question.
Noor et al. (2022) conducted a case report in COVID-19 and severe hypertriglyceridemia (n=1). Plasmapheresis was evaluated on Triglyceride level. Plasmapheresis successfully reduced severe hypertriglyceridemia from 9475 mg/dL to 128 mg/dL in a COVID-19 patient, coinciding with remarkable clinical improvement and successful extubation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: