Key result
Exercise-induced muscular injury, particularly from eccentric contractions, involves autogenetic disruption of myofilaments and sarcolemma damage, potentially driven by loss of intracellular Ca2+ homeostasis.
The review highlights that early events in exercise-induced muscle injury are autogenetic and likely driven by disruptions in intracellular calcium homeostasis.
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Implicates Ca2+ dysregulation in early eccentric injury; leaves open targeted mechanistic and interventional studies.
KIBLER et al. (1990) conducted a review in Exercise-induced muscular injury. Eccentric exercise was evaluated. Exercise-induced muscular injury, particularly from eccentric contractions, involves autogenetic disruption of myofilaments and sarcolemma damage, potentially driven by loss of intracellular Ca2+ homeostasis.
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