Key result
Adipose tissue-derived extracellular vesicles mediate metabolic homeostasis and represent promising targets for metabolic disorders.
Why the study?
Adipose tissue dysfunction leads to severe metabolic disorders, and extracellular vesicles have emerged as key mediators of metabolic homeostasis, though their roles, mechanisms, and clinical utility warrant synthesis.
Adipose tissue-derived extracellular vesicles represent a promising avenue for biomarker discovery and therapeutic intervention in metabolic disorders.
Should not yet change metabolic disorder management; leaves open prospective validation of adipose-derived EVs as biomarkers and targets.
Adipose tissue plays an important role in systemic energy metabolism, and its dysfunction can lead to severe metabolic disorders. Various cells in adipose tissue communicate with each other to maintain metabolic homeostasis. Extracellular vesicles (EVs) are recognized as novel medium for remote intercellular communication by transferring various bioactive molecules from parental cells to distant target cells. Increasing evidence suggests that the endocrine functions of adipose tissue and even the metabolic homeostasis are largely affected by different cell-derived EVs, such as insulin signaling, lipolysis, and metabolically triggered inflammation regulations. Here, we provide an overview focused on the role of EVs released by different cell types of adipose tissue in metabolic diseases and their possible molecular mechanisms and highlight the potential applications of EVs as biomarkers and therapeutic targets. Moreover, the current EVs-based therapeutic strategies have also been discussed. This trial is registered with NCT05475418.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2023) conducted a review in Metabolic disorders. Adipose tissue-derived extracellular vesicles was evaluated. Adipose tissue-derived extracellular vesicles serve as crucial mediators of metabolic homeostasis and represent promising biomarkers and therapeutic targets for metabolic disorders.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: