Key result
An 8-week relaxation response-based mind-body intervention regulated 1771 genes in blood pressure responders, with enrichment in immune regulatory, metabolic, and circadian rhythm pathways.
Why the study?
What are the transcriptome changes associated with blood pressure reduction following an 8-week relaxation response intervention in stage 1 hypertensive patients?
Population
24 stage 1 hypertensive patients (13 classified as blood pressure responders and 11 as nonresponders)
Comparison
8-week relaxation response-based mind-body… vs Nonresponders to the intervention
Design
Cohort
Follow-up
8 weeks
Authors
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May support mind-body approaches in hypertension; hypothesis-generating and should not yet change practice.
Observational (n=24)
What are the transcriptome changes associated with blood pressure reduction following an 8-week relaxation response intervention in stage 1 hypertensive patients?
Relaxation response training in hypertensive patients induces specific transcriptome changes, including modulation of immune, metabolic, and cardiovascular pathways, providing molecular insights into its blood pressure-lowering effects.
Bhasin et al. (2018) conducted an observational in Stage 1 hypertension (n=24). Relaxation response (RR)-based mind-body intervention vs. Nonresponders was evaluated on Transcriptome changes in peripheral blood mononuclear cells. An 8-week relaxation response-based mind-body intervention regulated 1771 genes in blood pressure responders, with enrichment in immune regulatory, metabolic, and circadian rhythm pathways.
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