Th1 subtypes, indicating that C5a-activated endothelial-iNOS may contribute to Th1 polarization in the peripheral LNs during homing. Finally, we observed C5a-mediated endothelial surface glycoprotein CD146 interaction with Th1 cell intermediate filament protein vimentin that may facilitate transmigration of activated Th1 cells into systemic circulation and tissue interstitium. Given the critical role of the C5a/C5ar1 axis in promoting lymphatic dysfunction, our study highlights the therapeutic potential of targeting C5ar1 in chronic inflammatory conditions.
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Rich et al. (2026) studied this question.
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