An AI algorithm using 12-lead ECG features predicted LVOT and RVOT locations of VT origin with an accuracy of 97.62% (95% CI 87.44-99.99) and an AUC of 98.99.
Does an artificial intelligence algorithm accurately predict RVOT vs LVOT origins of VT and PVC from 12-lead ECGs in patients undergoing catheter ablation?
A novel AI algorithm using 12-lead ECG features demonstrated clinical-grade precision in differentiating RVOT from LVOT origins of ventricular arrhythmias.
Several algorithms based on 12-lead ECG measurements have been proposed to identify right ventricular outflow tract (RVOT) and left ventricular outflow tract (LVOT) locations from which ventricular tachycardia (VT) and frequent premature ventricular complex (PVC) originated. However, a clinical-grade artificial intelligence algorithm is not available yet, which can automatically analyze characteristics of 12-lead ECGs and predict RVOT to LVOT origins of VT and PVC. We randomly sampled training, validation, and testing datasets from 420 patients who underwent successful catheter ablation (CA) to treat VT or PVCs, containing (340, 80%), (38, 9%), and (42, 10%) patients, respectively. We iteratively trained an AI algorithm that was supplied with 1,600,800 features extracted from 12-lead ECGs of the patients in the training cohort. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was calculated from the internal validation dataset to choose an optimal discretization cutoff threshold. After running on the testing dataset, the proposed approach attained the following performance metrics and 95% CIs (confidence intervals), accuracy (ACC) of 97.62 (87.44 -99.99), weighted F1-score of 98.46 (90-100), AUC of 98.99 (96.89-100), sensitivity (SE) of 96.97 (82.54-99.89), and specificity (SP) of 100 (62.97-100). The proposed multi-stage diagnostic scheme attained clinical-grade precision of prediction for LVOT and RVOT locations of VT origin with fewer applicability restrictions than prior studies.
Zheng et al. (Wed,) conducted a other in Ventricular tachycardia or frequent premature ventricular complex (n=420). AI algorithm based on 12-lead ECG measurements was evaluated on Prediction of RVOT to LVOT origins of VT and PVC (95% CI 87.44-99.99). An AI algorithm using 12-lead ECG features predicted LVOT and RVOT locations of VT origin with an accuracy of 97.62% (95% CI 87.44-99.99) and an AUC of 98.99.