Key result
This review highlights the pathophysiological mechanisms and main pathways leading to aging cardiomyopathy to better understand the clinical phenotype of heart failure in the elderly.
This review highlights the pathophysiological mechanisms of cardiovascular aging and their role in the development of heart failure in the elderly.
Enhances mechanistic framework for elderly HF; leaves open validation of targeted interventions in prospective studies.
: The rapid increase in the median age of the world's population requires particular attention towards older and more fragile people. Cardiovascular risk factors, time and comorbidities play a vicious role in the development of heart failure, both with reduced and preserved ejection fraction, in the elderly. Understanding the mechanisms underlying the pathophysiological processes observed with aging is pivotal to target those patients and their therapeutic needs properly. This review aims to investigate and to dissect the main pathways leading to the aging cardiomyopathy, helping to understand the relationship from bench to bedside of the clinical phenotype.
No takes yet. Share an insight, caveat, or question.
Cannatà et al. (2018) conducted a review in Cardiovascular aging and heart failure. Cardiovascular aging was evaluated. This review highlights the pathophysiological mechanisms and main pathways leading to aging cardiomyopathy to better understand the clinical phenotype of heart failure in the elderly.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: