Key result
Aging drives cardiovascular pathology via metabolic dysregulation and inflammation, underscoring targets to curb disease burden.
Why the study?
Aging causes progressive functional decline and increases cardiovascular disease risk, making the understanding of its clinical mechanisms crucial for developing targeted interventions to delay cardiovascular aging and reduce disease burden in older people.
This state-of-the-art review synthesizes the mechanisms of cardiovascular aging and highlights emerging therapeutic strategies, including gerotherapeutics and AI-powered approaches, to reduce CVD burden in older adults.
Answers are grounded in this paper and cite their sources.
Advances understanding of aging-CVD mechanisms; leaves open targeted interventions pending clinical validation.
Aging is an inevitable biological process marked by progressive functional decline and elevated risk of cardiovascular diseases (CVDs). This review systematically examines the clinical mechanisms linking aging to cardiovascular pathology, focusing on molecular, cellular, and physiological changes that contribute to cardiovascular aging, which in turn increases the incidence of heart failure, atherosclerosis, atrial fibrillation, and other diseases. Key mechanisms include metabolic dysregulation, mitochondrial dysfunction, chronic inflammation, cellular senescence, immune disorders, and epigenetic changes. Understanding these mechanisms is crucial for developing targeted interventions to delay cardiovascular aging and alleviate CVD burden in older people. Current therapeutic strategies, including lifestyle modifications, pharmacotherapy, gerotherapeutic interventions, and device-based management, are reviewed, along with future directions in precision medicine, development of novel therapeutic targets, multi-omics, and AI-powered strategies against cardiovascular aging.
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Liu et al. (2026) conducted a review in Cardiovascular diseases. Aging was evaluated. Aging drives cardiovascular pathology through mechanisms like metabolic dysregulation and inflammation, highlighting the need for targeted interventions to alleviate cardiovascular disease burden.
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