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December 26, 2007European Journal of Heart Failure

rAAV-asPLB Transfer Attenuates Abnormal Sarcoplasmic Reticulum Ca2+-ATPase Activity and Cardiac Dysfunction in Rats with Myocardial Infarction

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Why the study?

Does rAAV-asPLB gene transfer improve cardiac function and SERCA activity in a rat myocardial infarction model?

Population

Rat myocardial infarction (MI) model generated by ligating the left anterior descending coronary artery

Design

Preclinical

Follow-up

4 weeks

Key result

rAAV-asPLB gene transfer in rats with myocardial infarction effectively attenuated the depression of cardiac function, inhibited PLB expression, and enhanced SERCA activity.

Authors

XZXiaoyan ZhaoSHShen‐Jiang HuLJLi Jiang

Discussion

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Member takes

Overview

Preclinical support for SERCA restoration post-MI; leaves open safety, efficacy, and translation to human heart failure trials.

Structured PICO

Does rAAV-asPLB gene transfer improve cardiac function and SERCA activity in a rat myocardial infarction model?

P
Population
Rat myocardial infarction model evaluated 4 weeks after coronary artery ligation to assess the effects of rAAV-asPLB gene transfer.
I
Intervention
rAAV-antisense phospholamban (asPLB) gene transfer injected into the myocardium around the infarction area immediately after coronary artery ligation
O
Outcome
Cardiac function (LVEF, LVSP, +/-dp/dt(max), LVEDP), SERCA expression and activity, and PLB expression and phosphorylation (Pser16-PLB)surrogate

rAAV-asPLB gene transfer prevents the progression of heart failure in a rat model of myocardial infarction by restoring SERCA activity and inhibiting PLB expression.

Cite This Study

Zhao et al. (2007) studied Myocardial infarction. rAAV-antisense phospholamban (asPLB) gene transfer vs. Control rats with MI was evaluated on Cardiac function (LVEF, LVSP, +/-dp/dtmax, LVEDP), SERCA activity, and PLB expression. rAAV-asPLB gene transfer in rats with myocardial infarction effectively attenuated the depression of cardiac function, inhibited PLB expression, and enhanced SERCA activity.

synapsesocial.com/papers/6a1ff99791899344c12e6d29https://doi.org/10.1016/j.ejheart.2007.10.013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Restoration of Contractile Function in Isolated Cardiomyocytes From Failing Human Hearts by Gene Transfer of SERCA2a1999 · 508 citations
  2. 2Phospholamban: A Prominent Regulator of Myocardial Contractility1996 · 358 citations
  3. 3Dissociation of Regional Adaptations to Ischemia and Global Myolysis in an Accelerated Swine Model of Chronic Hibernating Myocardium2002 · 59 citations
  4. 4Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats2002 · 89 citations
  5. 5Targeting Phospholamban by Gene Transfer in Human Heart Failure2002 · 277 citations