Key result
An increased mean platelet volume (≥ 11.6 fl) was associated with a significantly higher risk of myocardial infarction compared to the lowest quintile (OR 2.6; 95% CI 1.3-5.1).
Why the study?
Does an increased mean platelet volume (≥ 11.6 fl) increase the risk of myocardial infarction in patients with coronary artery disease?
Population
373 patients, comprising 185 consecutive patients with stable coronary artery disease and 188 individuals…
Comparison
Highest quintile of mean platelet volume vs Lowest quintile of mean platelet volume
Design
Case-control
Authors
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May support MPV as a CAD risk marker; hypothesis-generating and should not yet change practice.
Case-Control (n=373)
Does an increased mean platelet volume (≥ 11.6 fl) increase the risk of myocardial infarction in patients with coronary artery disease?
Odds Ratio: 2.6 (95% CI 1.3–5.1)
An increased mean platelet volume (≥ 11.6 fl) is an independent risk factor for myocardial infarction in patients with pre-existing coronary artery disease, offering a simple marker for risk stratification.
Endler et al. (2002) conducted a case-control in Coronary artery disease and Myocardial infarction (n=373). Increased mean platelet volume (≥ 11.6 fl) vs. Lowest quintile of mean platelet volume was evaluated on Myocardial infarction (OR 2.6, 95% CI 1.3-5.1). An increased mean platelet volume (≥ 11.6 fl) was associated with a significantly higher risk of myocardial infarction compared to the lowest quintile (OR 2.6; 95% CI 1.3-5.1).
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