Key result
An increased mean platelet volume (≥ 11.6 fl) was associated with a significantly higher risk of myocardial infarction compared to the lowest quintile (OR 2.6; 95% CI 1.3-5.1).
Why the study?
Does an increased mean platelet volume (≥ 11.6 fl) increase the risk of myocardial infarction in patients with coronary artery disease?
Case-Control (n=373)
Does an increased mean platelet volume (≥ 11.6 fl) increase the risk of myocardial infarction in patients with coronary artery disease?
Odds Ratio: 2.6 (95% CI 1.3–5.1)
An increased mean platelet volume (≥ 11.6 fl) is an independent risk factor for myocardial infarction in patients with pre-existing coronary artery disease, offering a simple marker for risk stratification.
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May support MPV as a CAD risk marker; hypothesis-generating and should not yet change practice.
Endler et al. (2002) conducted a case-control in Coronary artery disease and Myocardial infarction (n=373). Increased mean platelet volume (≥ 11.6 fl) vs. Lowest quintile of mean platelet volume was evaluated on Myocardial infarction (OR 2.6, 95% CI 1.3-5.1). An increased mean platelet volume (≥ 11.6 fl) was associated with a significantly higher risk of myocardial infarction compared to the lowest quintile (OR 2.6; 95% CI 1.3-5.1).
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