Key result
Nonhypotensive lower body negative pressure produced a greater than twofold augmentation of the forearm vasoconstrictor response to neck pressure, demonstrating a specific inhibitory cardiopulmonary-carotid baroreflex interaction.
Why the study?
Does unloading of cardiopulmonary baroreceptors with nonhypotensive lower body negative pressure selectively augment reflex vasoconstrictor responses to simulated carotid hypotension in healthy humans?
Population
22 healthy male volunteers, ages 18-29 years, free of cardiovascular disease and not receiving any medication.
Comparison
Concomitant lower body negative pressure at -10… vs Lower body negative pressure alone and neck…
Design
The order of the five interventions was randomized.
Authors
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Does not support changes in clinical baroreflex assessment; leaves open relevance of cardiopulmonary-carotid interactions in hypertension or heart failure.
Does unloading of cardiopulmonary baroreceptors with nonhypotensive lower body negative pressure selectively augment reflex vasoconstrictor responses to simulated carotid hypotension in healthy humans?
Absolute Event Rate: 38.2% vs 31.1%
p-value: p=<0.05
Nonhypotensive lower body negative pressure selectively augments carotid baroreflex control of forearm vascular resistance, demonstrating a specific inhibitory cardiopulmonary-carotid baroreflex interaction in humans.
Victor et al. (1985) studied Healthy (n=22). Concomitant lower body negative pressure and neck pressure vs. Lower body negative pressure alone or neck pressure alone was evaluated on Forearm vascular resistance (p=<0.05). Nonhypotensive lower body negative pressure produced a greater than twofold augmentation of the forearm vasoconstrictor response to neck pressure, demonstrating a specific inhibitory cardiopulmonary-carotid baroreflex interaction.
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