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May 28, 2020Journal of Medicinal ChemistryOpen Access

Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis

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Key result

Modulation of the glycoprotein VI (GPVI) platelet receptor represents a novel antiplatelet strategy for thrombosis, with recent development focusing on small molecule modulators.

Why the study?

Despite existing anticoagulants and antiplatelet agents, thrombosis-related mortality remains high, prompting investigation into modulating the glycoprotein VI platelet receptor as a novel antiplatelet strategy.

Design

Review

Authors

HFHolly FosterCWClare WilsonHPHelen Philippou

Discussion

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Overview

GPVI modulation may offer a new antiplatelet approach in thrombosis; leaves open the need for clinical validation of small-molecule candidates.

Structured PICO

I
Intervention
Glycoprotein VI (GPVI) modulators (peptidic agents and small molecules)

Modulation of the glycoprotein VI (GPVI) platelet receptor represents a promising novel antiplatelet strategy for the treatment of thrombosis.

Cite This Study

Foster et al. (2020) conducted a review in Thrombosis. Glycoprotein VI (GPVI) modulators was evaluated. Modulation of the glycoprotein VI (GPVI) platelet receptor represents a novel antiplatelet strategy for thrombosis, with recent development focusing on small molecule modulators.

synapsesocial.com/papers/6a1ffaa7c1b320180d0dbb57https://doi.org/10.1021/acs.jmedchem.0c00262
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target2022 · 19 citations
  2. 2GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease2024 · 24 citations
  3. 3From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks2019 · 28 citations
  4. 4Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment2025 · 6 citations
  5. 5Targeting Glycoprotein VI for Thromboembolic Disorders2019 · 10 citations