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March 7, 2024European Heart Journal - Cardiovascular PharmacotherapyOpen Access

GPVI inhibitors, such as glenzocimab and revacept, represent a promising antithrombotic strategy for cardiovascular disease by targeting thrombosis without impairing haemostasis.

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Why the study?

GPVI plays a major role in thrombosis but not haemostasis, making it a promising antithrombotic target for cardiovascular disease.

Design

Review

Key result

GPVI inhibitors, such as glenzocimab and revacept, represent a promising antithrombotic strategy for cardiovascular disease by targeting thrombosis without impairing haemostasis.

Authors

ASAlexandre SlaterSKSophia KhattakMTMark R. Thomas

Discussion

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Overview

Supports advancing GPVI inhibitors into randomized cardiovascular trials; leaves open their integration into clinical practice.

Structured PICO

P
Population
Patients with cardiovascular disease, specifically atherothrombosis, stroke, and acute coronary syndromes
I
Intervention
GPVI inhibitors (including glenzocimab and revacept)

GPVI inhibition represents a promising antithrombotic strategy that targets thrombosis without impairing hemostasis, with several agents advancing in clinical trials.

Cite This Study

Slater et al. (2024) conducted a review in Cardiovascular disease. GPVI inhibitors was evaluated. GPVI inhibitors, such as glenzocimab and revacept, represent a promising antithrombotic strategy for cardiovascular disease by targeting thrombosis without impairing haemostasis.

synapsesocial.com/papers/6a6a3ff51997ff8660f1ee0ahttps://doi.org/10.1093/ehjcvp/pvae018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment2025 · 6 citations
  2. 2Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke2016 · 32 citations
  3. 3The quest for the holy grail in antithrombotic therapy: revitalized hope for platelet GPVI as a safe and effective antithrombotic target2024 · 9 citations
  4. 4From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks2019 · 28 citations
  5. 5Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis2020 · 7 citations