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October 10, 2011Current Drug Targets

Platelet glycoprotein VI and its soluble receptor show promise as biomarkers for risk stratification in atherosclerotic diseases and as potential targets for antithrombotic therapy.

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Key result

Platelet glycoprotein VI and its soluble receptor show promise as biomarkers for risk stratification in atherosclerotic diseases and as potential targets for antithrombotic therapy.

Authors

BBBoris BigalkeMEMargitta ElversTSTanja Schönberger

Discussion

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Overview

GPVI/soluble receptor warrant prospective validation as ACS biomarkers; leaves open therapeutic potential pending randomized trials.

PICO

P
Population
Acute coronary syndrome and ischemic stroke
I
Intervention / Comparator
Platelet and Soluble Glycoprotein VI

Platelet glycoprotein VI and its soluble form hold potential as biomarkers for early detection of ACS and as therapeutic targets for antithrombotic therapy.

Cite This Study

Bigalke et al. (2011) conducted a review in Acute coronary syndrome and ischemic stroke. Platelet and Soluble Glycoprotein VI was evaluated. Platelet glycoprotein VI and its soluble receptor show promise as biomarkers for risk stratification in atherosclerotic diseases and as potential targets for antithrombotic therapy.

synapsesocial.com/papers/6a844105356b31aeb3f2fd86https://doi.org/10.2174/138945011797635867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Glycoprotein VI: A Novel Marker for Acute Coronary Syndrome2007 · 27 citations
  2. 2Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI2010 · 15 citations
  3. 3Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment2025 · 6 citations
  4. 4Glycoprotein VI interplay with fibrin(ogen) in thrombosis2023 · 32 citations
  5. 5Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool2016 · 31 citations