Heritability of respiratory sinus arrhythmia: Dependency on task and respiration rate
Key result
Heritability of respiratory sinus arrhythmia ranged from 28% to 43% across rest and stress conditions, with mean RSA decreasing considerably from adolescence (111.5 ms) to middle age (60.0 ms).
Why the study?
What is the genetic and environmental heritability of respiratory sinus arrhythmia, and how is it affected by age, sex, and respiration rate?
Population
208 male and female pairs of middle-aged twins, combined with an earlier project dataset totaling 317…
Design
Cross-sectional
Authors
Discussion
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Implication
Supports moderate genetic contribution to RSA independent of sex; leaves open mechanisms of age-related decline for longitudinal confirmation.
Study Design
Type
Observational (n=1,029)
Structured PICO
What is the genetic and environmental heritability of respiratory sinus arrhythmia, and how is it affected by age, sex, and respiration rate?
P
Population
208 male and female pairs of middle-aged twins, combined with an earlier cohort for a total of 317 adolescents and 712 middle-aged individuals, to assess the heritability and age-related changes in respiratory sinus arrhythmia.
O
Outcome
Heritability of respiratory sinus arrhythmia (RSA) during rest and stress taskssurrogate
Main Result
Effect estimate: Heritability 28% to 43%
Respiratory sinus arrhythmia has a moderate heritability of 28-43% that is independent of sex but decreases significantly with age.
Cite This Study
Snieder et al. (1997) conducted an observational in Healthy (Respiratory sinus arrhythmia) (n=1,029). Genetic and environmental factors was evaluated on Heritability of respiratory sinus arrhythmia (RSA) (Heritability 28% to 43%). Heritability of respiratory sinus arrhythmia ranged from 28% to 43% across rest and stress conditions, with mean RSA decreasing considerably from adolescence (111.5 ms) to middle age (60.0 ms).