Why the study?
Does low forced vital capacity increase the risk of cardiovascular mortality and myocardial infarction in healthy men, and is this mediated by inflammation?
Population
5,064 healthy men aged 28 to 61 years
Comparison
Low forced vital capacity (FVC) (fourth quartile) vs Higher forced vital capacity (FVC)
Design
Cohort
Follow-up
mean 18.4 years
Key result
Low forced vital capacity was associated with an increased risk of cardiovascular death (RR 1.96; 95% CI 1.4-2.8), an excess risk that was partially explained by inflammation-sensitive proteins.
Authors
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May inform CV risk stratification in men; leaves open causal mediation by inflammation and need for prospective confirmation.
Cohort (n=5,064)
Does low forced vital capacity increase the risk of cardiovascular mortality and myocardial infarction in healthy men, and is this mediated by inflammation?
Relative Risk: 1.96 (95% CI 1.4–2.8)
Low forced vital capacity is associated with increased cardiovascular risk in healthy men, which is partially, but not fully, explained by elevated inflammation-sensitive plasma proteins.
Engström et al. (2002) conducted a cohort in Healthy (n=5,064). Low forced vital capacity (fourth quartile) vs. Top quartile of FVC was evaluated on Cardiovascular death (RR 1.96, 95% CI 1.4-2.8). Low forced vital capacity was associated with an increased risk of cardiovascular death (RR 1.96; 95% CI 1.4-2.8), an excess risk that was partially explained by inflammation-sensitive proteins.