Risk Factors for Acute Myocardial Infarction in Latin America
Key result
The Framingham cardiovascular risk score was not independently associated with a non-dipper blood pressure pattern after adjusting for blood pressure levels, whereas age (OR 1.06) and obesity (OR 1.82) were independent predictors.
Why the study?
What are the primary modifiable risk factors associated with first acute myocardial infarction in Latin America?
Population
1237 cases of first acute myocardial infarction and 1888 age-, sex-, and center-matched controls from…
Comparison
Presence of cardiovascular risk factors vs Absence of these risk factors or lower tertiles
Design
Case-control
Authors
Discussion
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Member takes
Implication
Obesity and age independently predict non-dipping beyond BP levels; hypothesis-generating for targeted interventions, prospective studies needed.
Study Design
Type
Cross-Sectional (n=308)
Multicenter
No
Structured PICO
What are the primary modifiable risk factors associated with first acute myocardial infarction in Latin America?
P
Population
308 participants from the CHICAMOCHA cohort (269 with probable hypertension and 39 controls) evaluated with ambulatory blood pressure monitoring after a median 12-year follow-up.
E
Exposure
Presence of cardiovascular risk factors (psychosocial stress, hypertension, diabetes mellitus, smoking, increased waist-to-hip ratio, increased apolipoprotein B to A-1 ratio)
C
Comparator
Absence of these risk factors or lower tertiles
O
Outcome
First acute myocardial infarctionhard clinical
Main Result
Absolute Event Rate: 74% vs 57%
p-value: p=0.039
Modifiable risk factors, particularly abdominal obesity, abnormal lipids, and smoking, account for 88% of the population-attributable risk for acute myocardial infarction in Latin America.
Cite This Study
Laņas et al. (2007) conducted a cross-sectional in Hypertension and Cardiovascular Risk (n=308). Framingham cardiovascular risk score (EFRCV) vs. Lower risk tertiles was evaluated on Non-dipper blood pressure pattern on ambulatory monitoring (p=0.039). The Framingham cardiovascular risk score was not independently associated with a non-dipper blood pressure pattern after adjusting for blood pressure levels, whereas age (OR 1.06) and obesity (OR 1.82) were independent predictors.