Why the study?
Are ACE I/D gene polymorphisms associated with an increased risk of atrial fibrillation?
Meta-Analysis
Are ACE I/D gene polymorphisms associated with an increased risk of atrial fibrillation?
Odds Ratio: 1.61 (95% CI 1.16–1.72)
Individuals with the ACE D/D genotype appear to be at a higher risk of developing atrial fibrillation, with significant associations observed in both Asian and Caucasian populations.
AIMS: The renin-angiotensin-aldosterone system is important to the development of atrial fibrillation (AF). A lot of research has focused on the relationship between angiotensin-converting enzyme (ACE) insertion (I) /deletion (D) gene polymorphisms and AF, with inconsistent results. A meta-analysis was carried out to find the correlation between ACE I/D gene polymorphisms and AF. METHODS: Data were extracted from articles published before September 2013 on ACE I/D polymorphisms and AF in Embase, PubMed, WanFangData, and China National Knowledge Infrastructure. RESULTS: The recessive model found that ACE I/D gene polymorphisms were related to AF (odds ratio (OR) = 1.61, 95% confidence interval (CI) = 1.16-1.72). Subgroup analysis showed a significant association in the recessive model for Asian (OR = 1.40, 95% CI = 1.19-1.80) and Caucasian (OR = 1.42, 95% CI = 1.01-1.99) populations. CONCLUSIONS: ACE I/D gene polymorphisms and AF are significantly related to ethnicity. Individuals with the ACE D/D genotype appear to be at higher risk of AF.
No takes yet. Share an insight, caveat, or question.
Ma et al. (2015) conducted a meta-analysis in Atrial fibrillation. ACE I/D gene polymorphisms vs. Other ACE genotypes was evaluated on Atrial fibrillation (OR 1.61, 95% CI 1.16-1.72).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: