Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Why the study?
Can noninvasive trans-thoracic echocardiography reliably measure right ventricular structure and function in a mouse model of pulmonary artery constriction?
Population
Adult mice undergoing a surgical model of pulmonary artery constriction (PAC) or sham operation
Comparison
Noninvasive trans-thoracic echocardiography… vs Sham operated mice and direct pressure…
Design
Preclinical
Follow-up
7 days
Authors
Discussion
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Member takes
Implication
Enables serial noninvasive RV monitoring in murine PAC models; leaves open translation to human pulmonary hypertension.
Structured PICO
Can noninvasive trans-thoracic echocardiography reliably measure right ventricular structure and function in a mouse model of pulmonary artery constriction?
P
Population
Adult mice undergoing a surgical model of pulmonary artery constriction (PAC) or sham operation
I
Intervention
Noninvasive trans-thoracic echocardiography (TTE) using a high-frequency ultrasound microimaging system
C
Comparator
Sham operated mice (for disease model) and direct pressure measurements with a Millar high-fidelity microtip catheter (for validation)
O
Outcome
Measurement of RV structure (RV wall thickness, end-diastolic and end-systolic dimensions) and function (fractional area change, fractional shortening, PA peak velocity, and peak pressure gradient)surrogate
Trans-thoracic echocardiography provides a reliable and noninvasive method to assess right ventricular structure and function in adult mice with pulmonary artery constriction.
Cite This Study
Cheng et al. (2014) studied this question.