In the early 1960s, practical epidemiology began to come under the influence of computing power. Before that time, epidemiologists had used ingenious devices such as the edge-punched card and hand-driven and even electrically driven calculating machines, all dependent on well known technology ingeniously applied. Regression analysis of study data was essentially unknown because the inversion of matrices beyond 3 x 3 by hand was far too time-consuming or well nigh impossible. Looking toward the future at that time, one would never have envisaged what in fact has taken place over the last 40 years.
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Florey et al. (2000) studied this question.
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