Key result
Reggie-1 and reggie-2 cluster at the plasmamembrane in noncaveolar micropatches in neurons, identifying sites where activated GPI-linked cell adhesion molecules preferentially accumulate.
Reggie-1 and reggie-2 identify noncaveolar micropatches in neurons where activated GPI-linked cell adhesion molecules accumulate, suggesting a role in transmembrane signaling.
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Does not inform clinical practice; leaves open reggie roles in neuronal adhesion signaling.
Lang et al. (1998) studied this question. Antibodies against reggie-1, reggie-2, and GPI-anchored CAMs was evaluated on Localization and clustering of reggie-1 and reggie-2 in neurons. Reggie-1 and reggie-2 cluster at the plasmamembrane in noncaveolar micropatches in neurons, identifying sites where activated GPI-linked cell adhesion molecules preferentially accumulate.
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