Key result
Overexpression of reggie-1 induced numerous filopodia-like protrusions in various cell lines, and its membrane association was shown to require myristoylation and palmitoylation.
Lipid modifications are essential for the membrane association of reggie-1, and its overexpression induces filopodia, suggesting a role in actin-dependent signaling processes.
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Does not yet inform clinical practice; leaves open reggie-1 relevance to cardiovascular cell signaling.
Neumann-Giesen et al. (2004) studied this question. reggie-1 overexpression and targeted substitutions was evaluated on membrane association and induction of filopodia-like protrusions. Overexpression of reggie-1 induced numerous filopodia-like protrusions in various cell lines, and its membrane association was shown to require myristoylation and palmitoylation.
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