Key result
Childhood doxorubicin treatment was associated with dose-dependent impairment of diastolic function and increased baseline end-systolic wall stress at cumulative doses >360 mg/m2.
Why the study?
Does doxorubicin treatment in childhood cause long-term impairment of cardiac performance in patients without overt congestive cardiomyopathy?
Population
n=55 patients evaluated at least two years after doxorubicin treatment in childhood, without overt…
Design
Cohort
Follow-up
at least two years
Authors
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May support echocardiographic surveillance in high-dose survivors; extends observational data but leaves causal effects and interventions open.
Observational (n=55)
Does doxorubicin treatment in childhood cause long-term impairment of cardiac performance in patients without overt congestive cardiomyopathy?
Childhood doxorubicin exposure causes dose-dependent long-term impairment in diastolic filling and increased baseline end-systolic wall stress, detectable by echocardiography prior to overt cardiomyopathy.
Hausdorf et al. (1988) conducted an observational in Doxorubicin cardiotoxicity (n=55). Doxorubicin was evaluated on Cardiac performance (contractile state and diastolic filling). Childhood doxorubicin treatment was associated with dose-dependent impairment of diastolic function and increased baseline end-systolic wall stress at cumulative doses >360 mg/m2.
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