What is the clinical evidence from this study?

Study design: Cohort. Population: Pediatric patients receiving doxorubicin (n=61). Intervention: Doxorubicin vs. Baseline (prior to chemotherapy). Primary outcome: Systolic and diastolic function.

January 1, 1994Acta OncologicaOpen Access

Cardiac Diastolic Function in Pediatric Patients Receiving Doxorubicin

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Key result

Doxorubicin treatment in children caused a small but significant decline in systolic cardiac function without significant changes in measured parameters of diastolic function.

Why the study?

Does doxorubicin chemotherapy alter systolic and diastolic echocardiographic parameters in pediatric patients?

Population

61 pediatric patients receiving doxorubicin chemotherapy, with no clinical evidence of cardiac…

Comparison

Doxorubicin chemotherapy vs Pre-treatment baseline

Design

Cohort

Authors

MEMichael S. EwerCardio-Oncology MAMohamed K. AliAssiut University HGHarry R. GibbsThe University of Texas MD Anderson Cancer Center

Discussion

Member takes

Overview

May support systolic-focused echocardiography for early detection in pediatric doxorubicin recipients; leaves open the added value of diastolic parameters at low doses.

Study Design

Type

Cohort (n=61)

Structured PICO

Does doxorubicin chemotherapy alter systolic and diastolic echocardiographic parameters in pediatric patients?

Population

61 children receiving relatively low cumulative doses of doxorubicin, with no prior clinical evidence of cardiac decompensation, evaluated prior to and following chemotherapy.

Exposure

Doxorubicin chemotherapy (relatively low cumulative doses, majority by continuous infusion)

Comparator

Pre-treatment baseline

Outcome

Systolic function (fractional shortening) and diastolic function (A wave velocity, E wave velocity, E to A ratio, and deceleration time)surrogate

In pediatric patients receiving low-dose doxorubicin, systolic function (fractional shortening) is a more sensitive marker of early cardiac changes than standard diastolic function parameters.

Cite This Study

Ewer et al. (1994) conducted a cohort in Pediatric patients receiving doxorubicin (n=61). Doxorubicin vs. Baseline (prior to chemotherapy) was evaluated on Systolic and diastolic function. Doxorubicin treatment in children caused a small but significant decline in systolic cardiac function without significant changes in measured parameters of diastolic function.

synapsesocial.com/papers/6aa3b4b0240321efda5553a7 https://doi.org/10.3109/02841869409121776

View Full Paper

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January 1, 1994Acta OncologicaOpen Access

Cardiac Diastolic Function in Pediatric Patients Receiving Doxorubicin

View Full Paper

Ask AI

Bookmark

Key result

Doxorubicin treatment in children caused a small but significant decline in systolic cardiac function without significant changes in measured parameters of diastolic function.

Why the study?

Does doxorubicin chemotherapy alter systolic and diastolic echocardiographic parameters in pediatric patients?

Population

61 pediatric patients receiving doxorubicin chemotherapy, with no clinical evidence of cardiac…

Comparison

Doxorubicin chemotherapy vs Pre-treatment baseline

Design

Cohort

Authors

MEMichael S. EwerCardio-Oncology MAMohamed K. AliAssiut University HGHarry R. GibbsThe University of Texas MD Anderson Cancer Center

Discussion

Member takes

Overview

May support systolic-focused echocardiography for early detection in pediatric doxorubicin recipients; leaves open the added value of diastolic parameters at low doses.

Study Design

Type

Cohort (n=61)

Structured PICO

Does doxorubicin chemotherapy alter systolic and diastolic echocardiographic parameters in pediatric patients?

Population

61 children receiving relatively low cumulative doses of doxorubicin, with no prior clinical evidence of cardiac decompensation, evaluated prior to and following chemotherapy.

Exposure

Doxorubicin chemotherapy (relatively low cumulative doses, majority by continuous infusion)

Comparator

Pre-treatment baseline

Outcome

Systolic function (fractional shortening) and diastolic function (A wave velocity, E wave velocity, E to A ratio, and deceleration time)surrogate

In pediatric patients receiving low-dose doxorubicin, systolic function (fractional shortening) is a more sensitive marker of early cardiac changes than standard diastolic function parameters.

Cite This Study

synapsesocial.com/papers/6aa3b4b0240321efda5553a7 https://doi.org/10.3109/02841869409121776

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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