Key result
Men with prevalent ischemic heart disease had significantly lower endogenous testosterone levels than those without the disease (20.9 vs. 22.0 nmol/liter, p<0.01).
Cross-Sectional (n=2,512)
Absolute Event Rate: 20.9% vs 22%
p-value: p=<0.01
Endogenous testosterone levels are inversely associated with prevalent ischemic heart disease in middle-aged men, but this relationship appears to be primarily mediated by insulin.
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Association does not support testosterone assessment or therapy in ischemic heart disease; leaves open insulin mediation and causality.
Lichtenstein et al. (1987) conducted a cross-sectional in Ischemic heart disease (n=2,512). Prevalent ischemic heart disease vs. No ischemic heart disease was evaluated on Endogenous testosterone levels (nmol/liter) (p=<0.01). Men with prevalent ischemic heart disease had significantly lower endogenous testosterone levels than those without the disease (20.9 vs. 22.0 nmol/liter, p<0.01).
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