What question did this study set out to answer?

To determine the relationship between circulating sex hormones, sex hormone-binding globulin, and serum lipid and lipoprotein concentrations in nondiabetic men.

December 1, 1993The Journal of Clinical Endocrinology & Metabolism

Relationship of sex hormones to lipids and lipoproteins in nondiabetic men.

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To determine the relationship between circulating sex hormones, sex hormone-binding globulin, and serum lipid and lipoprotein concentrations in nondiabetic men.
Analyzed cross-sectional data from 178 nondiabetic men participating in the San Antonio Heart Study.
Measured serum concentrations of sex hormone-binding globulin (SHBG), total and free testosterone, DHEA-SO4, estradiol, triglycerides, HDL cholesterol, LDL cholesterol, and total cholesterol.
Conducted correlation analyses with multivariable adjustment for age, body mass index, waist-to-hip ratio, and glucose and insulin levels.
Triglyceride concentrations were significantly inversely correlated with SHBG (r = -0.22), free testosterone (r = -0.15), total testosterone (r = -0.22), and DHEA-SO4 (r = -0.16).
HDL cholesterol was significantly positively correlated with SHBG (r = 0.21), free testosterone (r = 0.15), total testosterone (r = 0.17), and DHEA-SO4 (r = 0.16), remaining significant after full adjustment.
Total testosterone correlated inversely with total cholesterol (r = -0.17) and LDL cholesterol (r = -0.15).

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Implication

Cross-sectional study observes a less atherogenic lipid profile with higher testosterone in nondiabetic men, suggesting a sex-specific cardioprotective hormonal pattern.

Cite This Study

Haffner et al. (1993) studied this question.

synapsesocial.com/papers/6a7799869d809400dabd5e65 https://doi.org/10.1210/jcem.77.6.8263149

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Implication

Cross-sectional study observes a less atherogenic lipid profile with higher testosterone in nondiabetic men, suggesting a sex-specific cardioprotective hormonal pattern.

Relationship of sex hormones to lipids and lipoproteins in nondiabetic men.

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Discussion

Implication

Cite This Study

Relationship of sex hormones to lipids and lipoproteins in nondiabetic men.

Key Points

Discussion

Implication

Cite This Study

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