An increased number of cardiovascular comorbidities was associated with a higher 30-day in-hospital mortality rate in patients with congestive heart failure (HR up to 3.49; 95% CI 2.55-4.78; P<0.001).
Cohort (n=6,949)
Does the coexistence of multiple cardiovascular diseases increase 30-day mortality in hospitalized patients with congestive heart failure?
The coexistence of multiple cardiovascular comorbidities is an independent predictor of higher 30-day in-hospital mortality in patients admitted for congestive heart failure.
Hazard Ratio: 3.49 (95% CI 2.55–4.78)
valor p: p=<0.001
BACKGROUND: Congestive heart failure (CHF) has become a major clinical and public health challenge with the aging of the population in China. However, the effect of the coexistence of multiple cardiovascular diseases on the prognosis of hospitalized patients with CHF remains unclear. A comparative analysis was performed to explore the etiology and comorbidities of CHF and in-hospital mortality in patients with CHF. HYPOTHESIS: The coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with CHF. METHODS: All 6949 patients (4344 males, 2605 females) in the database with a principal ICD-9-CM discharge diagnosis of CHF were identified and divided into 5 groups according to the number of comorbidities. Cox proportional hazards regression was used to examine the association between the number of comorbidities and in-hospital mortality in patients with CHF. RESULTS: A single comorbidity was predominant in younger patients (18-39 years, P<0.001), whereas multiple comorbidities were predominant in the elderly (≥80 years, P<0.001). The most common single etiology was valvular heart disease, and the most common triple etiology was hypertension and diabetes mellitus complicated by coronary artery disease. Cox regression analysis showed a higher hospital mortality rate associated with an increased number of comorbidities (hazard ratio HR from 1.22 95% CI: 0.89-1.68 to HR 3.49 95% CI: 2.55-4.78, P<0.001). CONCLUSIONS: This study demonstrates the coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with CHF.
Yin et al. (Tue,) conducted a cohort in Congestive heart failure (n=6,949). Increased number of cardiovascular comorbidities vs. Fewer or single comorbidities was evaluated on 30-day in-hospital mortality (HR 3.49, 95% CI 2.55-4.78, p=<0.001). An increased number of cardiovascular comorbidities was associated with a higher 30-day in-hospital mortality rate in patients with congestive heart failure (HR up to 3.49; 95% CI 2.55-4.78; P<0.001).