Key result
A short-term bolus of intravenously administered heparin failed to increase circulating LPL or attenuate hypertriglyceridemia in two patients with complete GPIHBP1 deficiency.
Why the study?
Does intravenous heparin decrease plasma triglyceride levels in patients with complete GPIHBP1 deficiency?
Population
2 patients with complete GPIHBP1 deficiency and control individuals.
Comparison
Intravenous heparin bolus vs Control individuals
Design
Case_series
Follow-up
short-term
Authors
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Short-term IV heparin does not lower triglycerides in complete GPIHBP1 deficiency; leaves open whether alternative LPL-mobilizing strategies warrant testing in this rare chylomicronemia.
Case Report (n=2)
Does intravenous heparin decrease plasma triglyceride levels in patients with complete GPIHBP1 deficiency?
Complete GPIHBP1 deficiency due to a homozygous deletion causes severe chylomicronemia that is unresponsive to short-term intravenous heparin treatment.
Rios et al. (2011) conducted a case report in Severe chylomicronemia (n=2). Intravenous heparin bolus vs. Control individuals was evaluated on Circulating LPL and plasma triglyceride levels. A short-term bolus of intravenously administered heparin failed to increase circulating LPL or attenuate hypertriglyceridemia in two patients with complete GPIHBP1 deficiency.
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