Key result
The presence of Ca2+ increased the binding affinity between troponin-C and troponin-T by almost 1000-fold (Ka = 0.42 x 10^6 M^-1).
The variation of binding affinity between TnC and TnT as modulated by Ca2+ may play an important role in the Ca2+-regulation mechanism of muscle contraction.
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May aid Ca2+ regulation of contraction in vitro; leaves open translation to physiology or disease.
Lin et al. (1993) studied this question. Ca2+ vs. Absence of Ca2+ was evaluated on Binding affinity between TnC and TnT. The presence of Ca2+ increased the binding affinity between troponin-C and troponin-T by almost 1000-fold (Ka = 0.42 x 10^6 M^-1).
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