Key result
Circulating biomarkers, including cardiac troponins, natriuretic peptides, and oncological markers, highlight a bidirectional pathophysiological relationship between cancer and heart failure.
Why the study?
Cancer and heart failure share common pathophysiology and are thought to have a bidirectional relationship, making circulating biomarkers valuable to explore this link and evaluate treatment-naïve cancer patients.
Circulating cardiovascular biomarkers may help elucidate the bidirectional pathophysiological relationship between cancer and heart failure and assist in the risk stratification of treatment-naïve cancer patients.
May aid risk stratification in treatment-naïve cancer patients; leaves open whether routine use improves outcomes.
Cancer and heart failure are the two leading causes of death in developed countries. These two apparently distinct clinical entities share similar risk factors, symptoms, and pathophysiological mechanisms (inflammation, metabolic disturbances, neuro-hormonal and immune system activation, and endothelial dysfunction). Beyond the well-known cardiotoxic effects of oncological therapies, cancer and heart failure are thought to be tied by a bidirectional relationship, where one disease favors the other and vice versa. In this context, biomarkers represent a simple, reproducible, sensitive and cost-effective method to explore such relationship. In this review, we recapitulate the evidence on cardiovascular and oncological biomarkers in the field of cardioncology, focusing on their role in treatment-naïve cancer patients. Cardioncological biomarkers are useful tools in risk stratification, early detection of cardiotoxicity, follow-up, and prognostic assessment. Intriguingly, these biomarkers might contribute to better understand the common pathophysiology of cancer and heart failure, thus allowing the implementation of preventive and treatment strategies in cardioncological patients.
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Chianca et al. (2022) conducted a review in Cancer and Heart Failure. Circulating Biomarkers was evaluated. Circulating biomarkers, including cardiac troponins, natriuretic peptides, and oncological markers, highlight a bidirectional pathophysiological relationship between cancer and heart failure.
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