Key result
High-rate BNP infusion (1.4 micro g/h) in hypoxic rats lowered RV/BW (0.87 vs 1.02, P<0.05) and decreased %MPPV (60% vs 74%, P<0.05) compared to controls.
Why the study?
Does intravenous infusion of BNP or ANP prevent hypoxic pulmonary hypertension in rats?
Does intravenous infusion of BNP or ANP prevent hypoxic pulmonary hypertension in rats?
Absolute Event Rate: 0.87% vs 1.02%
p-value: p=< 0.05
High-dose intravenous BNP infusion blunts the development of hypoxic pulmonary hypertension and right ventricular hypertrophy in rats more effectively than ANP.
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Hypothesis-generating in rat hypoxic PH models; leaves open translation to human disease.
Klinger et al. (1998) studied Hypoxic pulmonary hypertension. Brain natriuretic peptide (BNP) vs. Saline alone or atrial natriuretic peptide (ANP) was evaluated on Right ventricle weight-to-body weight ratio (RV/BW) and percent muscularization of peripheral pulmonary vessels (%MPPV) (p=< 0.05). High-rate BNP infusion (1.4 micro g/h) in hypoxic rats lowered RV/BW (0.87 vs 1.02, P<0.05) and decreased %MPPV (60% vs 74%, P<0.05) compared to controls.
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