Key result
Atrial natriuretic factor increased particulate guanylate cyclase activity by about 10-fold, whereas sodium nitroprusside increased soluble guanylate cyclase activity by 17-fold in rat lung fibroblasts.
Population
Cultured rat lung fibroblasts
Design
Preclinical
Authors
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Distinguishes ANF and SNP pathways in rat fibroblasts; leaves open relevance to human cardiovascular cGMP signaling.
In cultured rat lung fibroblasts, ANF stimulates cyclic GMP entirely through particulate guanylate cyclase, whereas sodium nitroprusside acts via soluble guanylate cyclase.
Leitman et al. (1987) studied this question. Atrial natriuretic factor (ANF) and sodium nitroprusside was evaluated on Cyclic GMP levels and guanylate cyclase activity. Atrial natriuretic factor increased particulate guanylate cyclase activity by about 10-fold, whereas sodium nitroprusside increased soluble guanylate cyclase activity by 17-fold in rat lung fibroblasts.
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