Population
C6-2B rat glioma cells and PC12 rat pheochromocytoma cell cultures
Design
Preclinical
Follow-up
20 min
Authors
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May link ANF to neural cGMP signaling; hypothesis-generating for cardiovascular-neural interactions, no practice change.
Atrial natriuretic factors stimulate cyclic GMP accumulation and efflux in neurally derived cell lines, suggesting a potential mechanism for ANF action in the nervous system.
Fiscus et al. (1987) studied this question.
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