Why the study?
Does the combination of losartan and tempol reduce blood pressure in a rat model of renal hypertension?
Population
One-kidney, 1-clip rats (1K1C) or uninephrectomized controls (n=6 per group)
Comparison
Superoxide dismutase mimetic tempol (0.5… vs Untreated 1K1C rats
Design
Preclinical
Follow-up
2 weeks
Authors
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Hypothesis-generating for losartan-tempol synergy in experimental renal hypertension; leaves open translation to patients.
Does the combination of losartan and tempol reduce blood pressure in a rat model of renal hypertension?
Losartan and tempol have a synergistic effect on blood pressure reduction in renal hypertensive rats, potentially mediated by improved oxidative balance in the kidney.
Dobrian et al. (2001) studied this question.
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