Key result
Bleomycin, etoposide, and cisplatin chemotherapy linked to acute STEMI from complete thrombotic RCA occlusion.
Why the study?
Myocardial infarction in young individuals has unique risk factors compared to older populations, including medication-induced causes that warrant exploration.
Does bleomycin, etoposide, and cisplatin (PEB) chemotherapy cause ST-elevation myocardial infarction in young patients with embryonal carcinoma?
Case Report (n=1)
No
Does bleomycin, etoposide, and cisplatin (PEB) chemotherapy cause ST-elevation myocardial infarction in young patients with embryonal carcinoma?
Answers are grounded in this paper and cite their sources.
Bleomycin-containing chemotherapy regimens (such as PEB) may be associated with an increased risk of acute ST-elevation myocardial infarction and coronary thrombosis in young patients, highlighting the need for cardiovascular vigilance.
Myocardial infarction in young individuals has unique risk factors compared to the older population. Along with usual risk factors, one should explore causes such as recreational drug use, medication-induced myocardial infarction, and spontaneous coronary artery dissection. Here, we present the case of a 32-year-old male who presented with chest pain and was found to have complete thrombotic occlusion of the right coronary artery. He recently started receiving chemotherapy with bleomycin, etoposide, and cisplatin (PEB). In the absence of other risk factors and previous reports of similar cardiotoxicity with bleomycin, the patient was deemed to have an adverse effect from the chemotherapy regimen.
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Bassil et al. (2023) conducted a case report in Embryonal Carcinoma (n=1). Bleomycin, etoposide, and cisplatin (PEB) chemotherapy was evaluated on ST-Elevation Myocardial Infarction. A 32-year-old male developed an acute ST-elevation myocardial infarction due to complete thrombotic occlusion of the right coronary artery shortly after receiving bleomycin, etoposide, and cisplatin chemotherapy.
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