Highlights the rare risk of cisplatin-induced acute myocardial infarction, potentially mediated by vasospasm, in patients receiving chemoradiation.
May warrant vigilance for ACS during cisplatin chemoradiation; leaves open causal mechanisms for prospective study.
We present this unusual case of cisplatin-induced acute myocardial infarction in a patient with no organic coronary artery disease (CAD), receiving chemoradiation for small cell lung cancer. Patient developed symptoms of acute coronary syndrome after receiving two cycles of cisplatin and etoposide. The possible mechanism of vasospasm induced by cisplatin, in the background of thoracic radiation and hypomagnesemia, is discussed in this case report.
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Rao et al. (2015) studied this question.
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