What question did this study set out to answer?

To identify risk factors associated with silent lacunar stroke in elderly Japanese subjects.

June 1, 1996Arteriosclerosis Thrombosis and Vascular Biology

‘Silent’ Cerebral Infarction Is Associated With Hypercoagulability, Endothelial Cell Damage, and High Lp(a) Levels in Elderly Japanese

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Silent lacunar stroke (n=210). Intervention: Silent lacunar stroke vs. No lacunar infarcts (nonlacunar group). Primary outcome: Levels of fibrinogen and prothrombin fragment 1 + 2 (F1 + 2) (p=<.01).

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Key result

Silent multiple lacunar stroke in elderly Japanese patients is associated with hypercoagulability (higher fibrinogen and F1+2, P<0.01), endothelial cell damage, and high Lp(a) levels.

Why the study?

Are hypercoagulability, endothelial cell damage, and high Lp(a) levels associated with silent lacunar stroke in elderly Japanese patients?

Key Points

To identify risk factors associated with silent lacunar stroke in elderly Japanese subjects.
Conducted brain MRI and measured coagulation and endothelial activation markers in 178 high-risk asymptomatic Japanese subjects aged 44-93 years.
Analyzed fibrinogen, prothrombin fragment 1 + 2, von Willebrand factor, thrombomodulin, and Lp(a) levels across three groups.
Silent lacunar group had significantly higher fibrinogen and F1 + 2 levels compared to nonlacunar group (P < .01).
Symptomatic lacunar group showed higher mean Lp(a) levels and prevalence of Lp(a) > 30 mg/dL than nonlacunar group (P < .05).
Numerous-lacune subgroup had significantly elevated levels of Lp(a), F1 + 2, vWF, and thrombomodulin compared to few-lacune subgroup.

Study Design

Type

Cross-Sectional (n=210)

Structured PICO

Are hypercoagulability, endothelial cell damage, and high Lp(a) levels associated with silent lacunar stroke in elderly Japanese patients?

Population

210 Japanese subjects, including 178 asymptomatic high-risk individuals aged 44 to 93 years and 32 symptomatic patients with lacunar stroke, evaluated for coagulation and lipid markers.

Comparator

Subjects without lacunar infarcts (nonlacunar group)

Outcome

Levels of fibrinogen, prothrombin fragment 1 + 2 (F1 + 2), von Willebrand factor (vWF), thrombomodulin, and lipoprotein (a) [Lp(a)]surrogate

Main Result

p-value: p=<.01

Silent multiple lacunar strokes in asymptomatic elderly Japanese patients are associated with hypercoagulability, endothelial cell damage, and elevated Lp(a) levels.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating in elderly Japanese; prospective studies needed before considering Lp(a) or coagulation-targeted prevention.

Cite This Study

Kario et al. (1996) conducted a cross-sectional in Silent lacunar stroke (n=210). Silent lacunar stroke vs. No lacunar infarcts (nonlacunar group) was evaluated on Levels of fibrinogen and prothrombin fragment 1 + 2 (F1 + 2) (p=<.01). Silent multiple lacunar stroke in elderly Japanese patients is associated with hypercoagulability (higher fibrinogen and F1+2, P<0.01), endothelial cell damage, and high Lp(a) levels.

synapsesocial.com/papers/6a200e301517a826fb04e488 https://doi.org/10.1161/01.atv.16.6.734

Topics

Women and heart disease Hypertension management

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‘Silent’ Cerebral Infarction Is Associated With Hypercoagulability, Endothelial Cell Damage, and High Lp(a) Levels in Elderly Japanese

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

‘Silent’ Cerebral Infarction Is Associated With Hypercoagulability, Endothelial Cell Damage, and High Lp(a) Levels in Elderly Japanese

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider