Key result
A single haemodialysis session significantly elevated plasma levels of thrombomodulin from 38.4 ng/ml to 46.8 ng/ml (p<0.05) in patients with end-stage chronic glomerulonephritis.
Why the study?
Does haemodialysis affect plasma levels of thrombomodulin in patients with end-stage chronic glomerulonephritis?
Observational (n=49)
Does haemodialysis affect plasma levels of thrombomodulin in patients with end-stage chronic glomerulonephritis?
Absolute Event Rate: 46.8% vs 38.4%
p-value: p=<0.05
Haemodialysis increases plasma levels of thrombomodulin, suggesting potential endothelial cell damage, particularly in patients with greater residual blood volume in the dialyser.
May signal endothelial stress warranting vigilance in haemodialysis; hypothesis-generating for residual volume effects and thrombotic outcomes.
We studied the changes in plasma levels of thrombomodulin (TM) known to be present on vascular endothelial cells and released into circulating blood following damage to endothelial cells, during haemodialysis in 49 patients with end-stage chronic glomerulonephritis maintained on haemodialysis. After a single haemodialysis, plasma levels of TM were significantly elevated from 38.4 +/- 13.8 ng/ml to 46.8 +/- 14.6 ng/ml (p less than 0.05). Plasma levels of TM before haemodialysis were significantly higher in the cases of long-term haemodialysis than in those of short-term haemodialysis (p less than 0.01). From these observations, increased plasma levels of TM may be due to decreased clearance of TM by renal insufficiency, or damage to endothelial cells induced by the recurrent haemodialysis. In those patients with a greater residual blood volume in a dialyser, the changes in plasma levels of thrombin-antithrombin III complex and TM during a single haemodialysis were significantly higher. From these findings, it was suggested that endothelial cell damage is more severe in patients with greater residual blood volume.
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Yamazaki et al. (1992) conducted an observational in End-stage chronic glomerulonephritis (n=49). Haemodialysis vs. Before haemodialysis (baseline) was evaluated on Plasma levels of thrombomodulin (TM) (p=<0.05). A single haemodialysis session significantly elevated plasma levels of thrombomodulin from 38.4 ng/ml to 46.8 ng/ml (p<0.05) in patients with end-stage chronic glomerulonephritis.
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