October 15, 1995Circulation
Relation Between Ischemic Threshold Measured During Dobutamine Stress Echocardiography and Known Indices of Poor Prognosis in Patients With Coronary Artery Disease
Key result
The dobutamine ischemic threshold was significantly lower in patients with three-vessel disease (9.1 µg/kg/min) compared to two-vessel (14.4) and single-vessel disease (25.4) (P<0.0001).
Why the study?
Does the ischemic threshold measured during dobutamine stress echocardiography correlate with indices of poor prognosis in patients with coronary artery disease?
Population
104 patients with coronary artery disease (91 men, 13 women; mean age 61 +/- 9 years).
Design
Cross-sectional
Authors
Discussion
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Implication
Lower ischemic threshold may flag higher-risk multivessel CAD; leaves open its added prognostic value beyond angiography in prospective cohorts.
Study Design
Type
Observational (n=104)
Structured PICO
Does the ischemic threshold measured during dobutamine stress echocardiography correlate with indices of poor prognosis in patients with coronary artery disease?
P
Population
104 patients (12.5% female, mean age 61) with coronary artery disease evaluated with transesophageal echocardiography during dobutamine infusion.
E
Exposure
Transesophageal echocardiography during infusion of dobutamine 2.5 to 40 microgram/kg per minute to determine the ischemic threshold.
O
Outcome
Correlation of dobutamine ischemic threshold with the number of stenosed vessels and left ventricular ejection fraction response to exercise measured by radionuclide angiography.surrogate
Main Result
p-value: p=<.0001
The ischemic threshold measured during dobutamine stress echocardiography correlates with the number of stenosed vessels and adverse LVEF response to exercise, supporting its utility in evaluating patients with chronic coronary artery disease.
Cite This Study
Panza et al. (1995) conducted an observational in coronary artery disease (n=104). Dobutamine stress echocardiography was evaluated on Dobutamine ischemic threshold and its correlation with number of stenosed vessels (p=<.0001). The dobutamine ischemic threshold was significantly lower in patients with three-vessel disease (9.1 µg/kg/min) compared to two-vessel (14.4) and single-vessel disease (25.4) (P<0.0001).