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May 27, 1971New England Journal of Medicine216 citations

A Noninvasive Scintiphotographic Method for Detecting Regional Ventricular Dysfunction in Man

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BZBarry L. ZaretHSH. William StrausśPHPeter Hurley

Key Result

A noninvasive scintiphotographic technique successfully demonstrated localized areas of impaired left ventricular contraction in 8 of 11 patients, correlating well with contrast cineangiography.

Key Points

  • This research aims to evaluate a noninvasive method for detecting regional left ventricular dysfunction using scintiphotography.
  • Involves intravenous injection of technetium-99m-albumin
  • Utilizes an Anger scintillation camera for imaging
  • Compares scintiphotographic measurements with contrast cineangiography results
  • In eight out of eleven patients, localized impaired left ventricular contraction was identified by both scintiphotography and contrast radiography.
  • Changes in ventricular dimensions from scintiphotography correlated well with contrast cineangiography measurements.

Study Design

Type

Observational (n=11)

Structured PICO

Does a noninvasive scintiphotographic method accurately detect regional ventricular dysfunction compared to contrast cineangiography in patients with ventricular dysfunction?

P
Population
11 patients with ventricular dysfunction evaluated using scintiphotographic and contrast radiographic techniques.
E
Exposure
Noninvasive scintiphotographic technic (intravenous technetium-99m-albumin with electrocardiographically controlled cardiac images using an Anger scintillation camera)
C
Comparator
Contrast cineangiography / contrast radiographic technics
O
Outcome
Detection of regional left ventricular dysfunction (asynergy) and quantification of wall movementsurrogate

Noninvasive scintiphotography using technetium-99m-albumin provides a safe and accurate alternative to contrast cineangiography for assessing regional left ventricular function.

Abstract

Regional left ventricular dysfunction (asynergy) can be detected by a noninvasive scintiphotographic technic. After intravenous injection of radionuclide (technetium-99m-albumin) electrocardiographically controlled cardiac images (scintiphotographs) are obtained in end-systole and in end-diastole with an Anger scintillation camera. By superimposition of end-systolic and end-diastolic traced images, an assessment of left ventricular wall contraction can be made, and the extent of wall movement quantified. The changes in scintiphotographic ventricular dimensions correlate well with measurements obtained with contrast cineangiography. Eleven patients with ventricular dysfunction were studied by scintiphotographic and contrast radiographic technics. In eight of these, a localized area of impaired left ventricular contraction was demonstrated by both methods. This noninvasive technic appears to offer a safe and repeatable means for assessing regional left ventricular function.

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Cite This Study

Zaret et al. (1971) conducted an observational in Ventricular dysfunction (n=11). Noninvasive scintiphotographic technique (technetium-99m-albumin) vs. Contrast cineangiography was evaluated on Detection of localized area of impaired left ventricular contraction. A noninvasive scintiphotographic technique successfully demonstrated localized areas of impaired left ventricular contraction in 8 of 11 patients, correlating well with contrast cineangiography.

synapsesocial.com/papers/6a2010939d62e9997c04bd85https://doi.org/10.1056/nejm197105272842101
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