Key result
Extracellular matrix regulates cardiomyocyte contractile dynamics and actin isoform expression during differentiation.
Why the study?
Heart development and cardiomyocyte adaptation to culture both involve extracellular matrix changes, prompting this review on the role of the extracellular matrix in regulating cardiomyocyte contractile system dynamics.
Extracellular matrix changes play a crucial role in the maturation and regulation of the contractile apparatus in cardiomyocytes during development and in culture.
Does not alter clinical management; leaves open mechanistic studies of ECM-actin dynamics in cardiomyocyte models.
The contractile apparatus of cardiomyocytes is considered to be a stable system. However, it undergoes strong rearrangements during heart development as cells progress from their non-muscle precursors. Long-term culturing of mature cardiomyocytes is also accompanied by the reorganization of their contractile apparatus with the conversion of typical myofibrils into structures of non-muscle type. Processes of heart development as well as cell adaptation to culture conditions in cardiomyocytes both involve extracellular matrix changes, which appear to be crucial for the maturation of contractile apparatus. The aim of this review is to analyze the role of extracellular matrix in the regulation of contractile system dynamics in cardiomyocytes. Here, the remodeling of actin contractile structures and the expression of actin isoforms in cardiomyocytes during differentiation and adaptation to the culture system are described along with the extracellular matrix alterations. The data supporting the regulation of actin dynamics by extracellular matrix are highlighted and the possible mechanisms of such regulation are discussed.
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Natalya Bildyug (2019) conducted a review in Cardiomyocyte contractile system regulation. Extracellular matrix (ECM) was evaluated. The extracellular matrix regulates the dynamics of the contractile system and actin isoform expression in cardiomyocytes during differentiation and adaptation to culture conditions.
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