Key result
Exposure of chick myogenic cells to EMS killed 80% of replicating cells but allowed postmitotic myoblasts to survive and form myosheets where stress fiber-like structures functioned as early assembly sites for nascent myofibrils.
Population
Day 1 cultures of chick myogenic cells
Design
Preclinical
Follow-up
Up to 6 days after removal from EMS
Authors
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Does not inform clinical care; leaves open whether stress fiber-like structures mediate myofibrillogenesis beyond avian models.
Stress fiber-like structures act as transitory assembly sites for nascent myofibrils in chick myogenic cells recovering from EMS exposure.
Antin et al. (1986) studied Chick myogenic cells. Ethyl methanesulfonate (EMS) was evaluated on Cell survival and myofibril assembly. Exposure of chick myogenic cells to EMS killed 80% of replicating cells but allowed postmitotic myoblasts to survive and form myosheets where stress fiber-like structures functioned as early assembly sites for nascent myofibrils.
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