Key result
Among young adults with type 1 diabetes, 10.9% had coronary artery calcification, with smoking (P=0.03) and elevated Lp(a) (P=0.05) independently predicting its presence.
Why the study?
What is the prevalence of and what are the risk factors for early coronary artery calcification in young adults with type 1 diabetes?
Population
101 young adults aged 17-28 years with type 1 diabetes of over 5 years' duration and no history of heart…
Design
Cross-sectional
Authors
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May support risk assessment in young type 1 diabetes; leaves open whether modifying smoking or Lp(a) alters CAC progression.
Cross-Sectional (n=101)
What is the prevalence of and what are the risk factors for early coronary artery calcification in young adults with type 1 diabetes?
Effect estimate: nearly five times more likely (smoking); 10% increased risk per 0.36-mm/l increment (Lp[a])
p-value: p=0.03 (smoking); 0.05 (Lp[a])
Early coronary artery calcification is present in nearly 11% of young adults with type 1 diabetes, with smoking and elevated Lp(a) identified as independent risk factors.
Starkman et al. (2003) conducted a cross-sectional in Type 1 diabetes (n=101). Smoking and elevated Lipoprotein(a) vs. Nonsmokers and lower Lipoprotein(a) was evaluated on Presence of coronary artery calcification (CAC) (nearly five times more likely (smoking); 10% increased risk per 0.36-mm/l increment (Lp[a]), p=0.03 (smoking); 0.05 (Lp[a])). Among young adults with type 1 diabetes, 10.9% had coronary artery calcification, with smoking (P=0.03) and elevated Lp(a) (P=0.05) independently predicting its presence.
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