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December 1, 2002European Journal of Cardiovascular Prevention & Rehabilitation

Coronary Artery Calcification at Electron Beam Computed Tomography is Increased in Asymptomatic Type 2 Diabetics Independent of Traditional Risk Factors

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Key result

Asymptomatic type 2 diabetes was associated with an increased presence of coronary artery calcification compared to non-diabetics, independent of traditional risk factors (OR 2.9; 95% CI 1.1-7.8).

Why the study?

Does type 2 diabetes increase the presence and extent of coronary artery calcification in asymptomatic subjects independent of traditional risk factors?

Population

Asymptomatic subjects referred for electron beam computed tomography between 1996-1999, including type 2…

Comparison

Type 2 diabetes (exposure) vs Non-diabetics

Design

Cross-sectional

Authors

MWMegan L. WolfeUniversity of the SciencesNIN IqbalAmrita Institute of Medical Sciences and Research CentreWGWarren B. GefterRadboud University Nijmegen

Discussion

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Implication

Does not support routine CAC screening in asymptomatic diabetes; leaves open whether it refines risk prediction in longitudinal cohorts.

Study Design

Type

Observational (n=1,552)

Structured PICO

Does type 2 diabetes increase the presence and extent of coronary artery calcification in asymptomatic subjects independent of traditional risk factors?

P
Population
1,552 asymptomatic subjects referred for electron beam computed tomography between 1996 and 1999, including 71 with type 2 diabetes and 1,481 non-diabetics.
E
Exposure
Type 2 diabetes (exposure)
C
Comparator
Non-diabetics (both the entire cohort of n=1481 and a randomly selected group of n=71 matched for all traditional CVD risk factors)
O
Outcome
Presence and extent of coronary artery calcification (CAC) scores at electron beam computed tomography (EBCT)surrogate

Main Result

Odds Ratio: 2.9 (95% CI 1.1–7.8)

Asymptomatic type 2 diabetics have significantly higher coronary artery calcification scores than non-diabetics, independent of traditional cardiovascular risk factors.

Cite This Study

Wolfe et al. (2002) conducted an observational in Type 2 Diabetes (n=1,552). Type 2 diabetes vs. Non-diabetics was evaluated on Presence of coronary artery calcification (score > 0) (OR 2.9, 95% CI 1.1-7.8). Asymptomatic type 2 diabetes was associated with an increased presence of coronary artery calcification compared to non-diabetics, independent of traditional risk factors (OR 2.9; 95% CI 1.1-7.8).

synapsesocial.com/papers/6a9c41e45d361a92c1bb2c8chttps://doi.org/10.1177/174182670200900611
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors.2002 · 38 citations
  2. 2Increased Prevalence of Significant Coronary Artery Calcification in Patients With Diabetes2001 · 185 citations
  3. 3Delineation of Prevalence and Risk Factors for Early Coronary Artery Disease by Electron Beam Computed Tomography in Young Adults With Type 1 Diabetes2003 · 54 citations
  4. 4The association of coronary calcium score and conventional cardiovascular risk factors in Type 2 diabetic subjects asymptomatic for coronary heart disease (The PREDICT Study)2004 · 58 citations
  5. 5Coronary calcium in adults with type 1 diabetes: a stronger correlate of clinical coronary artery disease in men than in women.2000 · 158 citations