Key result
Alterations in calcium handling during cardiac hypertrophy and heart failure vary significantly depending on the animal model and disease stage, necessitating standardized longitudinal studies.
Population
Animal models and diseased human hearts with cardiac hypertrophy and heart failure
Design
Review
Authors
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Variability across animal models warrants caution extrapolating calcium data to human HF; leaves open whether standardized longitudinal studies will clarify mechanisms.
Consistent data on calcium handling abnormalities in cardiac hypertrophy and heart failure requires longitudinal studies using single animal models that mimic human disease.
C. William Balke (1998) conducted a review in Cardiac hypertrophy and heart failure. Alterations in calcium handling during cardiac hypertrophy and heart failure vary significantly depending on the animal model and disease stage, necessitating standardized longitudinal studies.
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