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June 7, 2013PLoS ONEOpen Access

Beneficial Effects of the Activation of the Angiotensin-(1–7) Mas Receptor in a Murine Model of Adriamycin-Induced Nephropathy

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Why the study?

Does activation of the Mas receptor with AVE 0991 or AT1 blockade with Losartan improve renal function and histology in a murine model of adriamycin-induced nephropathy?

Population

Male Balb/c, FVBN wild-type or FVBN Mas receptor knockout mice, 8-10 weeks old, with adriamycin-induced…

Comparison

Mas receptor agonist AVE 0991 or AT1 receptor… vs Vehicle orally daily from day 7 to day 14 after…

Design

Preclinical, randomly divided into 4 experimental groups, All scoring was…

Follow-up

21 days

Authors

KSKátia D. SilveiraUniversidade Federal de Minas GeraisLBLívia Corrêa BarrosoUniversidade Federal de Minas GeraisAVAngélica T. VieiraUniversidade Federal de Minas Gerais

Discussion

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Implication

Supports Mas receptor agonism in experimental nephropathy; leaves open translation to human CKD trials.

Structured PICO

Does activation of the Mas receptor with AVE 0991 or AT1 blockade with Losartan improve renal function and histology in a murine model of adriamycin-induced nephropathy?

P
Population
Male Balb/c, FVBN wild-type (Mas+/+) or FVBN Mas receptor knockout (Mas-/-) mice, 8-10 weeks old, with adriamycin (ADR)-induced nephropathy.
I
Intervention
Mas receptor agonist AVE 0991 (3 mg/kg orally daily) or AT1 receptor blocker Losartan (10 mg/kg orally daily) from day 7 to day 14 after ADR injection.
C
Comparator
Vehicle (tap water) orally daily from day 7 to day 14 after ADR injection.
O
Outcome
Renal function parameters (microalbuminuria, serum albumin, urinary/plasma creatinine) and renal histopathology (glomerular and tubular injury index).surrogate

Exogenous activation of the Mas receptor protects against adriamycin-induced nephropathy and is essential for the renoprotective effects of AT1 receptor blockade.

Cite This Study

Silveira et al. (2013) studied this question.

synapsesocial.com/papers/6a2017dea05ff06c2ba1a3echttps://doi.org/10.1371/journal.pone.0066082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas2003 · 1,818 citations
  2. 2Local Angiotensin II and Transforming Growth Factor-β1 in Renal Fibrosis of Rats2000 · 166 citations
  3. 3Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats1995 · 225 citations
  4. 4Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury2012 · 66 citations
  5. 5ACE2–angiotensin-(1–7)–Mas axis in renal ischaemia/reperfusion injury in rats2010 · 116 citations